Antifungal prophylaxis with micafungin in patients treated for childhood cancer.
作者： Shigenori Kusuki , Yoshiko Hashii , Hisao Yoshida , Sachiko Takizawa , Emiko Sato
DOI: 10.1002/PBC.22140
关键词:
摘要: Background Invasive fungal infections (IFIs) remain a major cause of infectious morality in neutropenic patients receiving chemotherapy or hematopoietic stem cell transplantation (HSCT). Micafungin exhibits broad antifungal activity against both Aspergillus and Candida species. We performed retrospective study to determine the efficacy safety prophylactic micafungin IFI pediatric during HSCT. Procedure Forty were given (3 mg/kg/day) intravenously for neutropenia: 131 patient-cycles (39 patients) after 15 (14 HSCT. Median duration neutropenia prophylaxis was 13 23 days HSCT, respectively. Results Treatment success rate, defined as absence proven, probable, possible, suspected IFIs, 93.9% (121/131) 80.0% (12/15) respectively. Proven probable documented only one patient No adverse events observed that could be related prophylaxis. Conclusions These results suggest is well tolerated may prevent IFIs with Pediatr Blood Cancer 2009;53:605–609. © 2009 Wiley-Liss, Inc.
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