Fibrinogen Genes and Myocardial Infarction : A Haplotype Analysis
作者： Werner Koch , Petra Hoppmann , Janita Biele , Jakob C. Mueller , Albert Schömig
DOI: 10.1161/ATVBAHA.107.157842
关键词: Genetics 、 Gene 、 Single-nucleotide polymorphism 、 Genotype 、 Myocardial infarction 、 Medicine 、 Fibrinogen 、 Haplotype 、 Pathology
摘要: Objective— Fibrinogen has a role in inflammatory processes and participates atherosclerotic plaque formation. Despite intensive investigation, there is no clear evidence for of variations the genes coding fibrinogen-α, fibrinogen-β, fibrinogen-γ polypeptide chains myocardial infarction. We examined association haplotypes 50-kb fibrinogen gene region with infarction 2 large case-control samples. Methods Results— Study sample 1 consisted 3657 patients 1211 control individuals comprised 1392 controls. Haplotypes were inferred from genotype analyses tagging single nucleotide polymorphisms dispersed among genes. The frequencies these not significantly different between case groups either (P≥0.07). In addition, specific individual analyzed. No substantial differences t...
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