Familial paracentric inversions inv(2)(q31q35) and inv(8)(q22.3q24.13) ascertained through reproductive abnormalities

摘要: Two cases of familial paracentric inversion, one in the long arm chromosome 2 and other 8, are described. The first was ascertained a woman who studied because recurrent abortions. second father girl with trichorhinophalangeal syndrome an interstitial deletion 8q. latter is case which unequal crossing over inversion loop can be inferred male carrier inversion. reasons for relatively low frequency inversions observed factors affect pregnancy outcome discussed.