Elevation of Cardiac Output and Oxygen Delivery Improves Outcome in Septic Shock

摘要: Septic shock is characterized by hypoperfusion and tissue energy defects. We prospectively evaluated the therapeutic benefit of augmenting cardiac output therefore oxygen delivery (Do 2 ) on mortality in patients with septic shock. Twenty-five were randomized to a normal treatment (NT) group 26 an optimal (OT) group. All had clinically evident site infection, sepsis as defined systemic response indicated hypoperfusion. Patients treated during initial 72 h algorithm differing only end point resuscitation. The index (CI) was increased 3.0 L/min/m NT 6 OT There no significant differences cardiorespiratory parameters groups entrance into study. During treatment, CI averaged 3.6 ± 0.2 Do 8.6 0.8 ml/min/kg 5.1 12.2 0.7 (p survival observed. Seventy-two percent died vs 50 = 0.14). Surviving stayed 13.7 3 days ICU 7.4 0.6 . 1 10.9 1.0 while >4.5 5.7 13.8 4.5 (Chest 1992; 102:216–20)