Synthesis of Novel Supramolecular Assemblies Based on Hyaluronic Acid Derivatives Bearing Bivalent β-Cyclodextrin and Adamantane Moieties

摘要: New supramolecular assemblies based on hyaluronic acid stabilized by divalent β-cyclodextrin/adamantane (β-CD/AD) complexes were synthesized with the aim to compare their viscoelastic behavior in aqueous medium systems resulting from monovalent complexes. For this purpose, dimers of AD and β-CD be coupled prepared multistep chemical synthetic pathways. Investigation complexation properties these isothermal titration calorimetry (ITC) experiments revealed a pronounced increase stability constant. These results can attributed divalency as suggested value enthalpy (ΔH0) which is twice that complex, agreement literature data. Nevertheless, decrease when fixed polysaccharide backbone was observed result an unfavorable entropy binding. The examined dynamic rheolo...