Mitochondrial Changes after Acute Alcohol Ingestion
作者： Hajimi Higuchi , Hiromasa Ishii
关键词: Hepatocyte 、 Mitochondrion 、 Chemistry 、 Intracellular 、 Oxidative stress 、 Apoptosis 、 Programmed cell death 、 Ethanol metabolism 、 Antioxidant 、 Cell biology
摘要: Active oxidants produced during ethanol metabolism modulate mitochondrial membrane potential and permeability changes in isolated cultured hepatocytes. These alterations (loss of ΔΨ;the MPT) are now recognized as a key step programmed cell death. Our fluorographic investigations demonstrate that acute ethanol-induced oxidative stress can induce change, cyto-chrome c release, caspase activation, apoptosis In addition, our implicate endogenous glutathioneglutathione peroxidase an impor-tant antioxidant with cytoprotective machinery hepatocyte mitochondria exposed to ethanol. Oxidative is the consequence imbalance between oxidant production defense. Development new effective strategies diminish production, enhance intracellular extracellular defenses, or both, liver offers great promise for preventing treating disease.
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