Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
作者： K Schulze-Osthoff , A.C. Bakker , B Vanhaesebroeck , R Beyaert , W.A. Jacob
DOI: 10.1016/S0021-9258(18)42768-8
关键词: Biochemistry 、 Coenzyme Q – cytochrome c reductase 、 Antimycin A 、 Electron Transport Complex I 、 Biology 、 Cytochrome c oxidase 、 Oxidative phosphorylation 、 Mitochondrial respiratory chain 、 Mitochondrion 、 Programmed cell death 、 Molecular biology
摘要: … Structural mitochondrial damage accompanies the cytotoxic effects of … damage of other cellular organelles. Analysis of the mitochondrial electron flow revealed that TNF treatment led to …
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