Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy

摘要: All living organisms respond to conditions such as mild heat shock, oxidative stress, reperfusion injury, or other stressful situations by increasing the expression of specific sets protective proteins that have been commonly referred for more than 30 years shock (hsps). Most, if not all, these are also expressed in absence stress. Many highly conserved function molecular chaperones guide changes conformational states critical synthesis, folding, translocation, assembly, and degradation (Hartl, 1996). Additionally, they can act inhibit irreversible aggregation denatured caused protein-damaging stresses and, some instances, assist refolding (Craig et al., 1993; Gething Sambrook, 1992). The principal hsps mammalian cells be classified into several sequence-related families characterized size, i.e., hsp25/hsp27 (small protein), hsp40 (J-domain proteins), hsp60, hsp70, hsp90, hsp110/Sse family. regulation is coordinated transcription factors (HSFs) interact with elements (HSEs) promoters hsp genes (Morimoto 1997). principally found cytoplasm, nucleus, mitochondria.