Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

摘要: Stress-induced proteins (or heat shock (HSPs)) of 96 kDa size (gp96) have been shown previously to elicit specific immunity tumors from which they are isolated. In this report, we show that in contrast Meth A-derived gp96, gp96 preparations derived normal tissues did not A sarcoma at any dose tested. Further, light recent studies showing other major cellular HSPs hsp90 and hsp70 also tumor-specific immunity, compared the relative immunogenicities hsp90, sarcoma. The were observed be highly equally immunogenic, whereas immunogenicity was approximately 10% or hsp70. It is suggested poor results its lack a measurable ATPase activity, has implicated ability transfer peptide acceptor molecules. This first study documents compares each three one tumor system.