Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIV-infected men who have sex with men.

摘要: The incidence of anal cancer is elevated in human immunodeficiency virus (HIV)-infected men-who-have-sex-with-men (MSM) compared to the general population. Anal high-grade squamous intraepithelial lesions (HSIL) are common HIV-infected MSM and presumed precursors cell cancer; however, direct progression HSIL has not been previously demonstrated. medical records were reviewed 138 followed up at University California, San Francisco, who developed canal or perianal between 1997 2011. Men regularly with digital anorectal examination (DARE), high-resolution anoscopy (HRA) HRA-guided biopsy. Although treatment for follow-up recommended, all treated some lost follow-up. Prevalent was found 66 men. Seventy-two while under observation. In 27 men, a biopsied site HSIL. An additional 45 men analyzed this analysis due inadequate documentation relation location. Of documented biopsy-proven HSIL, 20 progressed from prevalent identified when first examined seven incident over an average 57 months 64 Most asymptomatic, cancers detected by DARE. clear potential progress MSM. Early diagnosis facilitated careful Carefully controlled studies evaluating efficacy screening prevent needed.