Establishing an Anal Neoplasia Screening Service for a Unique HIV Positive Patient Population in a Small City: Lessons Learned
作者： Charles D. Sturgis
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摘要: Mortality from human papillomavirus (HPV) mediated squamous carcinoma of the uterine cervix has dramatically decreased in recent decades as a result broad scale population screening for early detection cervical cancer precursors. Concomitantly, deaths associated with HPV related carcinomas anus have oppositely trended upward. At this time, there are no national guidelines anal screening. We herein report our experience establishing an cytology program HIV infected patients small city. The positive studied is unique that 75% had undetectable viral loads by PCR average CD4+ cell/uL counts 550. In addition 40% adult females. 45% relatively healthy HIV+ were discovered to atypical cells or worse on entry into screening, and 20% ultimately shown high resolution anoscopic biopsy histology harbor grade intraepithelial lesions (AIN 2/3). Meaningful programs possible clinical collaborations. It seems simple inexpensive test may prevent morbidity mortality carcinoma.
ivyunion.org参考文章(30)
William Christopher Mathews, Edward R Cachay, Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals. Aids Reviews. ,vol. 15, pp. 122- ,(2013)
David M Aboulafia, Lacey L Siekas, Establishing an anal dysplasia clinic for HIV-infected men: initial experience. Aids Reader. ,vol. 19, pp. 178- ,(2009)
J. Michael Berry, Naomi Jay, Ross D. Cranston, Teresa M. Darragh, Elizabeth A. Holly, Mark L. Welton, Joel M. Palefsky, Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIV-infected men who have sex with men. International Journal of Cancer. ,vol. 134, pp. 1147- 1155 ,(2014) , 10.1002/IJC.28431
Teresa M. Darragh, Diane Tokugawa, Philip E. Castle, Stephen Follansbee, Sylvia Borgonovo, Brandon J. LaMere, Lauren Schwartz, Julia C. Gage, Barbara Fetterman, Thomas Lorey, Nicolas Wentzensen, Interrater agreement of anal cytology. Cancer Cytopathology. ,vol. 121, pp. 72- 78 ,(2013) , 10.1002/CNCY.21218
George Kurdgelashvili, Graça M. Dores, Samer A. Srour, Anil K. Chaturvedi, Mark M. Huycke, Susan S. Devesa, Incidence of potentially human papillomavirus–related neoplasms in the United States, 1978 to 2007 Cancer. ,vol. 119, pp. 2291- 2299 ,(2013) , 10.1002/CNCR.27989
M. M. Madeleine, J. L. Finch, C. F. Lynch, M. T. Goodman, E. A. Engels, HPV-related cancers after solid organ transplantation in the United States. American Journal of Transplantation. ,vol. 13, pp. 3202- 3209 ,(2013) , 10.1111/AJT.12472
Vivian Colón-López, Ana Patricia Ortiz, Lizbeth Del Toro-Mejías, Michael Craig Clatts, Joel M. Palefsky, 6. Prevalence, genotype diversity and determinants of anal HPV infection in high-risk men attending a sexually transmitted infection clinic in Puerto Rico Sexual Health. ,vol. 10, pp. 572- 573 ,(2013) , 10.1071/SHV10N6AB6
Teresa M. Darragh, Barbara Winkler, Rhona J. Souers, Rodolfo Laucirica, Chengquan Zhao, Ann T. Moriarty, Room for improvement: initial experience with anal cytology: observations from the College of American Pathologists interlaboratory comparison program in nongynecologic cytology. Archives of Pathology & Laboratory Medicine. ,vol. 137, pp. 1550- 1554 ,(2013) , 10.5858/ARPA.2012-0574-CP
Laila Darwich, Mari-Paz Cañadas, Sebastian Videla, Josep Coll, Rafael A Molina-López, Guillem Sirera, Bonaventura Clotet, Can Ruti HIV-HPV Team, Prevalence, clearance, and incidence of human papillomavirus type-specific infection at the anal and penile site of HIV-infected men. Sexually Transmitted Diseases. ,vol. 40, pp. 611- 618 ,(2013) , 10.1097/01.OLQ.0000430798.61475.08
Teresa M Darragh, Terence J Colgan, J Thomas Cox, Debra S Heller, Michael R Henry, Ronald D Luff, Timothy McCalmont, Ritu Nayar, Joel M Palefsky, Mark H Stoler, Edward J Wilkinson, Richard J Zaino, David C Wilbur, David C Wilbur, Teresa M Darragh, Michael R Henry, Timothy McCalmont, Ronald D Luff, Edward J Wilkinson, J Thomas Cox, Edward J Wilkinson, Dennis M O'Connor, R Kevin Reynolds, M Angelica Selim, James Scurry, Michael R Henry, David Chelmow, Lydia P Howell, Brigitte Ronnett, Alan G Waxman, Timothy McCalmont, Hope K Haefner, Kieron S Leslie, Christopher Shea, Paul N Staats, Joel M Palefsky, Leona Council, Alice Lytwyn, Barbara Winkler, Jennifer Roberts, Terence J Colgan, Levi Downs, Rodolfo Laucirica, Richard J Zaino, Debra S Heller, Jill Allbritton, Olga Ioffe, Nancy Joste, Teresa M Darragh, J Michael Berry, Oscar Lin, Mark Welton, Christopher N Otis, David C Wilbur, Mark H Stoler, Joel S Bentz, Christina S Kong, Bradley Quade, Mary R Schwartz, Ronald D Luff, Ritu Nayar, Philip E Castle, Maire Duggan, Francisco AR Garcia, Ann T Moriarty, G Chip Niedt, Alicia Carter, Marc Goodman, Margaret Neal, Vijaya Reddy, Stanley Robboy, Mona Saraiya, Steven Silverberg, Susan Spires, None, The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology Archives of Pathology & Laboratory Medicine. ,vol. 136, pp. 1266- 1297 ,(2012) , 10.5858/ARPA.LGT200570