MicroRNA: master controllers of intracellular signaling pathways

摘要: Signaling pathways are essential intracellular networks that coordinate molecular outcomes to external stimuli. Tight regulation of these is ensure an appropriate response. MicroRNA (miRNA) a class small, non-coding RNA regulates gene expression at post-transcriptional level by binding the complementary sequence on target mRNA, thus limiting protein translation. Intracellular controlled regulators, such as suppressor cytokine signaling and A20. Until recently, classical regulators was thought be solely transcriptional induction proteasomal degradation; however, there growing body evidence describing their miRNA. This new information has transformed our understanding cell adding previously unknown layer regulatory control. review outlines miRNA describes broad effects both cellular disease levels. We three important pathways, including JAK/STAT, NF-κB, TGF-β summarize extensive catalog regulating miRNAs. highlights importance regulon reveals landscape must included in identification development novel therapeutic targets for clinical disorders.