Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice.
作者： Xiao Yu , Ning Shen , Ming-Liang Zhang , Fei-Yan Pan , Chen Wang
关键词: Insulin 、 Protein kinase B 、 Endocrinology 、 Downregulation and upregulation 、 Adipocyte 、 Insulin resistance 、 MAPK/ERK pathway 、 PI3K/AKT/mTOR pathway 、 Biology 、 Internal medicine 、 Hyperinsulinism
摘要: … of Egr-1 in adipose tissue, we overexpressed Egr-1 in wild-type mice and inhibited Egr-1 transcriptional activity in diabetic db/db mice by injecting adenovirus carrying either Egr-1 or its …
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