Off-period dystonia in Parkinson's disease but not generalized dystonia is improved by high-frequency stimulation of the subthalamic nucleus.

摘要: STN-HFS is well known to improve patients with IPD. Because off-period dystonia mimics focal or generalized of other causes, we proposed bilateral some dystonia. The aim this study was compare the efficacy STN stimulation on and From a larger series IPD, selected 22 based presence severe preoperative rated > = 3 in least one limb severity score ranging from 0 4. Four (Hallervorden-Spatz disease, n 3; primary, 1) underwent STN-HFS. Dystonia four limbs video recordings all before surgery months after surgery. In reduced by 70% (preoperative mean 2.03 +/- 1.49; postoperative 0.60 0.78). contrast, had no effect 3.25 0.77; 3.12 0.62). Despite clinical similarities between Parkinson's disease certain cases, chronic differs. highly effective whereas it does not pathophysiologic mechanisms underlying these two disorders are still unknown. Assuming that mechanism action similar regardless cause dystonia, our findings suggest similarly involved IPD others dystonias.