Treatment of Dystonia with Deep Brain Stimulation

摘要: Pallidal deep brain stimulation (DBS) is an established treatment option for medically refractive dystonia. The mechanism by which globus pallidus pars interna (GPi) DBS improves dystonia still unclear. Primary generalized usually responds well to this therapy, as recently confirmed in two well-designed, double-blind, controlled trials; however, predictors of outcome within population are not known. role GPi idiopathic cervical resistant with botulinum toxin, tardive dystonia, and some types secondary emerging populations patients who may also benefit, but outcomes documented. Serious complications from therapy rare. Future research will likely continue address the most appropriate programming settings various affects possibility alternative targets that might have less associated side effects or greater efficacy than GPi.