Factor XI promotes hemostasis in factor IX‐deficient mice
作者： B. M. Mohammed , Q. Cheng , A. Matafonov , D. M. Monroe , J. C. M. Meijers
DOI: 10.1111/JTH.14243
关键词: Tail vein 、 Medicine 、 Deficient mouse 、 Internal medicine 、 Factor IX 、 Hemostasis 、 Endocrinology 、 Coagulation factor XI 、 Vein 、 Plasma levels 、 Phenotype
摘要: Essentials Mice lacking factor IX (FIX) or XI (FXI) were tested in a saphenous vein bleeding model. FIX-deficient mice displayed hemostatic defect and FXI-deficient similar to wild type mice. Infusion of FXI over-expression improved hemostasis. may affect the phenotype FIX-deficiency (hemophilia B). Summary Background In humans, deficiency coagulation be associated with disorder, but, until recently, did not appear have abnormality. A recent study, however, indicated that show moderate (SVB) Objectives To study effect on normal levels substrate FIX (a murine model hemophilia Methods Wild-type either (F9- ) (F11-/- SVB The plasma F11-/- manipulated by infusion its active form FXIa, overexpressing use hydrodynamic tail injection. Results F9- showed significant model, whereas wild-type indistinguishable. Intravenous FXIa into, overexpression in, hemostasis Overexpression variant FIX-binding site also Conclusions Although we unable demonstrate our results support premise supraphysiological improve through FIX-independent pathways.
narcis.nl参考文章(29)
Brooks M, Dodds Wj, Giger U, Knowler C, FACTOR XI DEFICIENCY IN KERRY BLUE TERRIERS Javma-journal of The American Veterinary Medical Association. ,vol. 205, pp. 1557- 1561 ,(1994)
Hui-Feng Lin, Nobuyo Maeda, Oliver Smithies, David L. Straight, Darrel W. Stafford, A Coagulation Factor IX-Deficient Mouse Model for Human Hemophilia B Blood. ,vol. 90, pp. 3962- 3966 ,(1997) , 10.1182/BLOOD.V90.10.3962
A. E. PASTOFT, J. LYKKESFELDT, M. EZBAN, M. TRANHOLM, H. C. WHINNA, B. LAURITZEN, A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII products (N8 and Advate®) Haemophilia. ,vol. 18, pp. 782- 788 ,(2012) , 10.1111/J.1365-2516.2012.02780.X
X. WANG, Q. CHENG, L. XU, G. Z. FEUERSTEIN, M-Y. HSU, P. L. SMITH, D. A. SEIFFERT, W. A. SCHUMACHER, M. L. OGLETREE, D. GAILANI, Effects of factor IX or factor XI deficiency on ferric chloride‐induced carotid artery occlusion in mice Journal of Thrombosis and Haemostasis. ,vol. 3, pp. 695- 702 ,(2005) , 10.1111/J.1538-7836.2005.01236.X
M. F. WHELIHAN, T. ORFEO, M. T. GISSEL, K. G. MANN, Coagulation procofactor activation by factor XIa Journal of Thrombosis and Haemostasis. ,vol. 8, pp. 1532- 1539 ,(2010) , 10.1111/J.1538-7836.2010.03899.X
G. N. Pike, P. H. B. Bolton-Maggs, Factor XI-related thrombosis and the role of concentrate treatment in factor XI deficiency. Haemophilia. ,vol. 21, pp. 477- 480 ,(2015) , 10.1111/HAE.12678
Magdolna G. Sebestyén, Vladimir G. Budker, Tatiana Budker, Vladimir M. Subbotin, Guofeng Zhang, Sean D. Monahan, David L. Lewis, So C. Wong, James E. Hagstrom, Jon A. Wolff, Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules Journal of Gene Medicine. ,vol. 8, pp. 852- 873 ,(2006) , 10.1002/JGM.921
Jonathan W. Yau, Peng Liao, James C. Fredenburgh, Alan R. Stafford, Alexey S. Revenko, Brett P. Monia, Jeffrey I. Weitz, Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits Blood. ,vol. 123, pp. 2102- 2107 ,(2014) , 10.1182/BLOOD-2013-12-540872
D. Gailani, N. M. Lasky, G. J. Broze, A murine model of factor XI deficiency. Blood Coagulation & Fibrinolysis. ,vol. 8, pp. 134- 144 ,(1997) , 10.1097/00001721-199703000-00008
Anton Matafonov, Erik I. Tucker, Mao-fu Sun, Peter N. Walsh, Andras Gruber, David Gailani, Dmitri V. Kravtsov, Factor XI contributes to thrombin generation in the absence of factor XII Blood. ,vol. 114, pp. 452- 458 ,(2008) , 10.1182/BLOOD-2009-02-203604