Comparative uterine gene expression analysis after dioxin and estradiol administration
作者： H Watanabe , A Suzuki , M Goto , S Ohsako , C Tohyama
DOI: 10.1677/JME.1.01529
关键词: Endocrinology 、 Uterus 、 Biology 、 Gene 、 Endocrine effects 、 Gene expression 、 Internal medicine 、 Estrogen
摘要: The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) adversely affects many organisms. TCDD exposure is known to be associated with abnormal development, hepatotoxicity and endocrine effects. It has also been reported have antiestrogenic activity in addition estrogenic activity. In order clarify the effects of uterus, we evaluated patterns gene expression after estradiol administration. Of 10 000 arrayed genes, only a few were affected by both TCDD. Although subset genes that responded estrogen was activated TCDD, response more limited than observed estradiol. Therefore, according our analysis patterns, had partial weak uterus.
bioscientifica.com
endocrinology-journals.org参考文章(28)
C.M. Sadek, B.L. Allen-Hoffmann, Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway. Journal of Biological Chemistry. ,vol. 269, pp. 31505- 31509 ,(1994) , 10.1016/S0021-9258(18)31723-X
Sung-Woo Kim, Masaaki Hayashi, Jeng-Fan Lo, Young Yang, Jin-San Yoo, Jiing-Dwan Lee, ADP-ribosylation Factor 4 Small GTPase Mediates Epidermal Growth Factor Receptor-dependent Phospholipase D2 Activation Journal of Biological Chemistry. ,vol. 278, pp. 2661- 2668 ,(2003) , 10.1074/JBC.M205819200
Sherry Rier, Warren G Foster, Environmental dioxins and endometriosis. Toxicological Sciences. ,vol. 70, pp. 161- 170 ,(2002) , 10.1093/TOXSCI/70.2.161
Yanan Tian, Sui Ke, Michael. S. Denison, Arnold B. Rabson, Michael A. Gallo, Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity Journal of Biological Chemistry. ,vol. 274, pp. 510- 515 ,(1999) , 10.1074/JBC.274.1.510
F Y Bois, B Eskenazi, Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin. Environmental Health Perspectives. ,vol. 102, pp. 476- 477 ,(1994) , 10.1289/EHP.94102476
A Gibbons, Dioxin tied to endometriosis Science. ,vol. 262, pp. 1373- 1373 ,(1993) , 10.1126/SCIENCE.8248776
A. Manz, D. Flesch-Janys, H. Waltsgott, J. Berger, S. Nagel, J.H. Dwyer, Cancer mortality among workers in chemical plant contaminated with dioxin The Lancet. ,vol. 338, pp. 959- 964 ,(1991) , 10.1016/0140-6736(91)91835-I
John M. Rosenfeld, Reynaldo Vargas, Wen Xie, Ronald M. Evans, Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Molecular Endocrinology. ,vol. 17, pp. 1268- 1282 ,(2003) , 10.1210/ME.2002-0421
M.A. Gallo, E.J. Hesse, G.J. MacDonald, T.H. Umbreit, Interactive effects of estradiol and 2,3,7,8-tetrachloro-dibenzo-p-dioxin on hepatic cytochrome P-450 and mouse uterus Toxicology Letters. ,vol. 32, pp. 123- 132 ,(1986) , 10.1016/0378-4274(86)90058-5
C. Li, W. H. Wong, Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 31- 36 ,(2001) , 10.1073/PNAS.98.1.31