Constitutive activity of nuclear transcription factor kappaB is observed in follicular lymphoma.

摘要: Constitutive activity of nuclear transcription factor kappaB (NF-kappaB) is observed in many pathological types lymphoma that are associated with a poor clinical course. This suggests NF-kappaB and pathways involving possible targets for successfully treating lymphoma. We examined 28 lymph nodes from patients whom follicular was diagnosed 1996 to 2006 at our institution, which were formalin-fixed paraffin-embedded. The specimens stained an antibody could recognize activated p65 determine whether they positive or negative activation. courses the then correlated results staining. 10 men 18 women had mean age 57.3 years (range, 25-87 years). By grade, grade 1, 16 2, 2 3a. Ten died due 6 cases. Analysis staining groups while taking into account course, sex, age, lymphoma, prognostic index, CD10, CD23, Bcl-2, karyotype t(14;18), survival showed no significant differences. Six (21.4%) exhibited consistent activity. Three eleven cases transformed aggressive NF-kappaB. Further research clarify significance constitutive therefore warranted.