Regulation of human T cell leukemia virus expression 1
作者： Patrick L. Green , Irvin S. Y. Chen
DOI: 10.1096/FASEBJ.4.2.2404818
关键词: Retrovirus 、 Virus 、 Genetics 、 Virology 、 Mutagenesis (molecular biology technique) 、 Murine leukemia virus 、 Jurkat cells 、 Biology 、 Replication Competent Retrovirus 、 Gene 、 Viral transformation 、 Biotechnology 、 Biochemistry 、 Molecular biology
摘要: Retroviruses of the type C morphology have been implicated in a wide variety diseases animals and humans. The human T cell leukemia viruses types I (HTLV-I) II (HTLV-II), prototypic human-type retroviruses, identified as causative agents some forms neurological disorders. genetic structure regulation HTLVs are more complex than their avian murine virus counterparts. In addition to gag, pol, env genes that encode characteristic virion proteins all replication competent genomes HTLV non-structural proteins, Tax Rex, which required for regulating viral gene expression. To understand what appears be mechanism disease induction by HTLV, elucidating function products interaction these with each other, well cellular factors, will critical. This review focuses primarily on ...
fasebj.org 参考文章(24)
J Brady, K T Jeang, J Duvall, G Khoury, Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. Journal of Virology. ,vol. 61, pp. 2175- 2181 ,(1987) , 10.1128/JVI.61.7.2175-2181.1987
A. Bernstein, Robin Weiss, RNA tumor viruses University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers. ,(1982)
M. Hidaka, J. Inoue, M. Yoshida, M. Seiki, Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins. The EMBO Journal. ,vol. 7, pp. 519- 523 ,(1988) , 10.1002/J.1460-2075.1988.TB02840.X
M Ohta, H Nyunoya, H Tanaka, T Okamoto, T Akagi, K Shimotohno, Identification of a cis-regulatory element involved in accumulation of human T-cell leukemia virus type II genomic mRNA. Journal of Virology. ,vol. 62, pp. 4445- 4451 ,(1988) , 10.1128/JVI.62.12.4445-4451.1988
M. Seiki, J. Inoue, M. Hidaka, M. Yoshida, Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 7124- 7128 ,(1988) , 10.1073/PNAS.85.19.7124
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, W Wachsman, The x gene is essential for HTLV replication. Science. ,vol. 229, pp. 54- 58 ,(1985) , 10.1126/SCIENCE.2990037
R. Grassmann, C. Dengler, I. Muller-Fleckenstein, B. Fleckenstein, K. McGuire, M. C. Dokhelar, J. G. Sodroski, W. A. Haseltine, Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a herpesvirus saimiri vector Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 3351- 3355 ,(1989) , 10.1073/PNAS.86.9.3351
M. Seiki, S. Hattori, M. Yoshida, Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structure Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 6899- 6902 ,(1982) , 10.1073/PNAS.79.22.6899
ROBERT GALLO, FLOSSIE WONG-STAAL, LUC MONTAGNIER, WILLIAM A. HASELTINE, MITSUAKI YOSHIDA, HIV/HTLV gene nomenclature Nature. ,vol. 333, pp. 504- 504 ,(1988) , 10.1038/333504A0
Mitsuhiro Osame, Koichiro Usuku, Shuji Izumo, Naomi Ijichi, Hiroyoko Amitani, Akihiro Igata, Makoto Matsumoto, Mitsutoshi Tara, HTLV-I ASSOCIATED MYELOPATHY, A NEW CLINICAL ENTITY The Lancet. ,vol. 327, pp. 1031- 1032 ,(1986) , 10.1016/S0140-6736(86)91298-5