Differential proliferative response of fetal and adult human skin fibroblasts to transforming growth factor-beta

摘要: Since pronounced differences exist between the fetal and adult repair processes, we studied proliferative response of skin fibroblasts from these two stages to transforming growth factor-beta (TGF-beta), a cytokine with broad range activities in tissue repair. Here, present evidence that TGF-beta inhibits human fibroblasts, while it is stimulatory for ones. This effect was found be concentration- dependent, but isoform-independent. Furthermore, even transient exposure cells this factor sufficient exert its or inhibitory action. Accordingly, have immediate responses provoked by major signaling pathways, induces rapid activation SMAD pathway, i.e., phosphorylation nuclear translocation SMAD2, followed dephosphorylation, most probably due degradation proteasome. However, similar intensity kinetics been observed both fibroblasts. On other hand, curcumin, natural product wound healing properties several intracellular completely abrogate TGF-beta1 on without affecting action donors. In conclusion, there radical TGF-beta, possibly reflecting different strategies development.