作者: Walter B. Severs , Patricia A. Klase
DOI: 10.1016/0091-3057(78)90174-0
关键词: Internal medicine 、 Angiotensin II 、 Angiotensin-converting enzyme 、 Endocrinology 、 Angiotensin III 、 Angiotensin receptor 、 Saralasin 、 Angiotensin II receptor antagonist 、 Angiotensin II receptor type 1 、 Renin–angiotensin system 、 Chemistry
摘要: Saralasin, an angiotensin II receptor antagonist, is ineffective in reducing drinking after water-deprivation (WD). Angiotensin III has considerable dipsogenic potency. It may be formed without as intermediate. To clarify whether formation masks a role for WD, 48 hr WD rats were infused via lateral cerebroventricle with a) CSF, b) c) SQ 20,881, converting enzyme inhibitor, or d) Saralasin + SQ. No drug effect on was observed. The results demonstrate that not required drinking.