Drinking in water deprived rats after combined central angiotensin receptor and converting enzyme blockade.

作者: Walter B. Severs , Patricia A. Klase

DOI: 10.1016/0091-3057(78)90174-0

关键词: Internal medicineAngiotensin IIAngiotensin-converting enzymeEndocrinologyAngiotensin IIIAngiotensin receptorSaralasinAngiotensin II receptor antagonistAngiotensin II receptor type 1Renin–angiotensin systemChemistry

摘要: Saralasin, an angiotensin II receptor antagonist, is ineffective in reducing drinking after water-deprivation (WD). Angiotensin III has considerable dipsogenic potency. It may be formed without as intermediate. To clarify whether formation masks a role for WD, 48 hr WD rats were infused via lateral cerebroventricle with a) CSF, b) c) SQ 20,881, converting enzyme inhibitor, or d) Saralasin + SQ. No drug effect on was observed. The results demonstrate that not required drinking.

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