Angiotensin and thirst: studies with a converting enzyme inhibitor and a receptor antagonist.
作者： Joan Summy-Long , Walter B. Severs
DOI: 10.1016/0024-3205(74)90354-3
关键词: Receptor antagonist 、 Renin–angiotensin system 、 Enzyme inhibitor 、 Endocrinology 、 Chemistry 、 Thirst 、 Angiotensin II 、 Dipsogen 、 Angiotensin Receptor Antagonists 、 Tonicity 、 Internal medicine
摘要: Abstract Although exogenous angiotensin is recognized as a potent dipsogen, the participation of endogenous in thirst has not been well established. To investigate this question, we produced rats by relative cellular dehydration (hypertonic NaCl injection), or hypovolemia (hyperoncotic polyethylene glycol injection). An receptor antagonists (sar(1)-ala(8)- II, P-113), converting enzyme inhibitor (SQ, 20, 881, SQ) given to thirsty intracerebroventricular (IVT) peripheral routes. P-113 infused i.v. (10 μg/kg/min) injected IVT μg) did alter drinking response either stimulus. The latter treatment reduced 50 ng II (p
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