Epidemiology of Nosocomial Fungal Infections, with Emphasis on Candida Species

摘要: Currently, about 180 hospitals participate in the National Nosocomial Infections Surveillance (NNIS) system. From January 1980 through April 1990, 27,200 fungal isolates causing nosocomial infections were reported from these hospitals; Candida species accounted for 19,621 (72.1%) of isolates. Immunocompromised patients are at particularly high risk candidemia. In with acute lymphocytic leukemia, treatment vancomycin and/or imipenem appears to be an independent factor candidemia; colonization stool by may another important predisposing patients. Rapid detection invasive candidemia high-risk is improvement rates survival. Methods rapid detection, such as measurement mannan (the major cell-wall polysaccharide Candida), useful diagnosing candidiasis and monitoring response this infection antifungal therapy. Further studies factors development new methods diagnosis should help decrease morbidity mortality associated infections.