Relationship between the use of Chinese herbal medicines and Sjögren syndrome risk among women with menopause: a retrospective cohort study.

摘要: Objective Menopausal women appear to report a higher risk of Sjogren syndrome (SS). Although Chinese herbal medicines (CHMs) are proven lower SS risk, the scientific evidence whether it can lessen occurrence among menopausal is limited. This longitudinal cohort study aimed clarify relationship between CHMs use and in women. Methods Using nationwide claims data, we enrolled 31,917 with first-time diagnosed menopause who simultaneously were free 2000 2007. Among them, randomly selected 12,757 users non-CHMs using propensity scores matching. All participants followed until end 2012 record incidence. The hazard ratio regard was estimated Cox proportional hazards regression model. Results In follow-up period, 589 644 developed SS, representing incidence rates 5.12 6.40, respectively, per 1,000 person-years. associated 21% subsequent (adjusted ratio, 0.79; 95% CI, 0.71-0.89). Six commonly prescribed discovered be risk: Ge-Gen-Tang, Zhi-Gan-Cao-Tag, Da-Huang, Ye-Jiao-Teng, Tian-Hua-Fen, Bo-Zi-Ren. Conclusions A statistically significant association found onset women, suggesting that could considered integrate into conventional therapy reduce for