Symptomatic Menopausal Transition Increases the Risk of New-Onset Depressive Disorder in Later Life: A Nationwide Prospective Cohort Study in Taiwan
作者： Mu-Hong Chen , Tung-Ping Su , Cheng-Ta Li , Wen-Han Chang , Tzeng-Ji Chen
DOI: 10.1371/JOURNAL.PONE.0059899
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摘要: Introduction The role of the menopausal transition and associated menopausal symptoms in the occurrence of depressive disorders has been discussed and debated for a long time. Most previous clinical studies had limited case samples, and did not control the attributable risk of medical comorbidities. Methods Patients with a diagnosis of symptomatic menopausal transition and without a psychiatric history were enrolled in 2000 in Taiwan, and compared with age-matched controls (1∶ 4). These subjects were followed to the end of 2010 to …
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