Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus
作者： Yutaka Ueda , Fan-Yan Wei , Taku-ichiro Hide , Hiroyuki Michiue , Kentaro Takayama
DOI: 10.1016/J.BIOMATERIALS.2012.09.003
关键词: Cancer stem cell 、 Cell growth 、 Embryonic stem cell 、 Cell culture 、 Cell 、 Glioma 、 Molecular biology 、 Programmed cell death 、 Apoptosis 、 Biology
摘要: Glioblastoma multiforme (GBM) is the most aggressive and fatal brain tumor. GBM resistant to chemotherapy radiation. Recent studies have shown that glioma-initiating cells (GICs), which characteristics of cancer stem cells, are responsible for resistance radiation regrowth. No effective therapy GICs has been developed. Here we showed D-isomer peptides (dPasFHV-p53C') consisting a cell-penetrating peptide (FHV), penetration accelerating sequence (Pas) C-terminus p53 (p53C') induced cell death GICs. dPasFHV-p53C' was effectively transduced into human The dose-dependently inhibited growth at 3 μM completely blocked but not embryonic cells. Autophagic observed in treated with apoptosis not. dPasFHV without p53C' same effect as dPasFHV-p53C', suggesting Pas play critical role Finally, reduced tumor mass mice transplanted Peptide transduction using could be new method treatment GBM.
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