摘要: Both stem cells and cancer are thought to be capable of unlimited proliferation. Moreover, many tumours cell lines express markers, including adenosine triphosphate (ATP)-binding cassette transporters, by which the pump out specific fluorescent dyes as well anti-cancer drugs, suggesting either that resemble or cancers contain stem-like cells. Using common characteristics brain tumour neural cells, several research groups have succeeded in identifying (cancer cells) lines. The purified but not other self-renew form when transplanted vivo. Thus, might a crucial target for anti-brain therapy.
elsevier.com
sci-hub.se 参考文章(82)
Sheng Zhou, John D. Schuetz, Kevin D. Bunting, Anne-Marie Colapietro, Janardhan Sampath, John J. Morris, Irina Lagutina, Gerard C. Grosveld, Mitsujiro Osawa, Hiromitsu Nakauchi, Brian P. Sorrentino, The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype Nature Medicine. ,vol. 7, pp. 1028- 1034 ,(2001) , 10.1038/NM0901-1028
Makoto Ikeya, Scott M. K. Lee, Jane E. Johnson, Andrew P. McMahon, Shinji Takada, Wnt signalling required for expansion of neural crest and CNS progenitors Nature. ,vol. 389, pp. 966- 970 ,(1997) , 10.1038/40146
Sally Temple, The development of neural stem cells Nature. ,vol. 414, pp. 112- 117 ,(2001) , 10.1038/35102174
Ryoichiro Kageyama, Nobuo Hashimoto, Gerald Gradwohl, Masato Hojo, Toshiyuki Ohtsuka, Francois Guillemot, Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina Development. ,vol. 127, pp. 2515- 2522 ,(2000) , 10.1242/DEV.127.12.2515
S. Tole, E. Grove, A.P. McMahon, S.M. Lee, A local Wnt-3a signal is required for development of the mammalian hippocampus. Development. ,vol. 127, pp. 457- 467 ,(2000) , 10.1242/DEV.127.3.457
Eric C. Holland, Gregory N. Fuller, Lene Uhrbom, Marc K. Rosenblum, Joseph C. Celestino, Chengkai Dai, Ink4a-Arf Loss Cooperates with KRas Activation in Astrocytes and Neural Progenitors to Generate Glioblastomas of Various Morphologies Depending on Activated Akt Cancer Research. ,vol. 62, pp. 5551- 5558 ,(2002)
Janet Rossant, Chi Chung Hui, Stéphan Gasca, Hiroshi Sasaki, Rong Mo, Jun Motoyama, Qi Ding, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. ,vol. 125, pp. 2533- 2543 ,(1998) , 10.1242/DEV.125.14.2533
Corey Raffel, Sharon A. Chiappa, Russell H. Zurawel, Cory Allen, Sporadic Medulloblastomas Contain Oncogenic β-Catenin Mutations Cancer Research. ,vol. 58, pp. 896- 899 ,(1998)
Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari, Ajamete Kaykas, WNT and β-catenin signalling: diseases and therapies Nature Reviews Genetics. ,vol. 5, pp. 691- 701 ,(2004) , 10.1038/NRG1427
Kenji Tanigaki, Fumiaki Nogaki, Jun Takahashi, Kei Tashiro, Hisanori Kurooka, Tasuku Honjo, Notch1 and Notch3 Instructively Restrict bFGF-Responsive Multipotent Neural Progenitor Cells to an Astroglial Fate Neuron. ,vol. 29, pp. 45- 55 ,(2001) , 10.1016/S0896-6273(01)00179-9