The Effect of Hypercapnia on Brain Permeability to Protein
作者： R. W. P. CUTLER , C. F. BARLOW
DOI: 10.1001/ARCHNEUR.1966.00470070058007
关键词: Inhalation 、 Central nervous system 、 Biophysics 、 Permeability (electromagnetism) 、 Carbon dioxide 、 Blood proteins 、 Blood flow 、 Hypercapnia 、 Chemistry 、 Biochemistry 、 CATS
摘要: HYPERCAPNIA is known to influence the penetration of a variety substances into brain. Investigations have ranged from effect carbon dioxide inhalation on regional uptake trifluoroiododomethane labeled with radioactive iodine (131I),1a rapidly penetrating compound that essentially measures blood flow, entry viruses and colloidal carbon,2particles ordinarily limited access central nervous system. In addition, accumulation various drugs3and ions4,5has been studied in hypercapnic animal. An analysis results these latter experiments has required consideration enhanced changes ionization drugs secondary increased hydrogen ion activity, alteration degree metabolic incorporation or binding brain plasma. Other studies implied pathological increase blood-brain permeability plasma proteins. Clemedson et al6exposed rabbits, guinea pigs, cats
sci-hub.se 参考文章(30)
Marian W. Kies, Sigmund Schwimmer, OBSERVATIONS ON PROTEINASE IN BRAIN Journal of Biological Chemistry. ,vol. 145, pp. 685- 691 ,(1942) , 10.1016/S0021-9258(18)51311-9
N MARKS, A LAJTHA, PROTEIN BREAKDOWN IN THE BRAIN. SUBCELLULAR DISTRIBUTION AND PROPERTIES OF NEUTRAL AND ACID PROTEINASES. Biochemical Journal. ,vol. 89, pp. 438- 447 ,(1963) , 10.1042/BJ0890438
Margret I. Sellers, John F. Lavender, Studies on the interrelationship between the blood-brain barrier and entry of viruses into the central nervous system. I. The effect of carbon dioxide on type II poliovirus infection in mice. Journal of Experimental Medicine. ,vol. 115, pp. 107- 130 ,(1962) , 10.1084/JEM.115.1.107
F. Zizza, T. J. Campbell, E. B. Reeve, The Nature and Rates of Excretion of Radioactive Breakdown Products of I131-Albumin in the Rabbit Journal of General Physiology. ,vol. 43, pp. 397- 413 ,(1959) , 10.1085/JGP.43.2.397
Douglas B. Hansen, Mary R. Sultzer, Walter H. Freygang, Louis Sokoloff, EFFECTS OF LOW O2 AND HIGH CO2 CONCENTRATIONS IN INSPIRED AIR ON LOCAL CEREBRAL CIRCULATION Survey of Anesthesiology. ,vol. 1, pp. 437- ,(1957) , 10.1097/00132586-195710000-00028
W. C. Hsieh, S.-P. Wang, A. F. Rasmussen, Prophylactic therapy of Japanese encephalitis passive immunization combined with CO2 inhalation. Experimental Biology and Medicine. ,vol. 112, pp. 267- 269 ,(1963) , 10.3181/00379727-112-28012
R. W. P. CUTLER, G. V. WATTERS, C. F. BARLOW, I125-Labeled Protein in Experimental Brain Edema JAMA Neurology. ,vol. 11, pp. 225- 238 ,(1964) , 10.1001/ARCHNEUR.1964.00460210003001
C.-J. Clemedson, H. Hartelius, G. Holmberg, THE INFLUENCE OF CARBON DIOXIDE INHALATION ON THE CEREBRAL VASCULAR PERMEABILITY TO TRYPAN BLUE (‘THE BLOOD-BRAIN BARRIER’) Acta Pathologica Microbiologica Scandinavica. ,vol. 42, pp. 137- 149 ,(2009) , 10.1111/J.1699-0463.1958.TB03178.X
Edith A. Maynard, Robert L. Schultz, Daniel C. Pease, Electron microscopy of the vascular bed of rat cerebral cortex American Journal of Anatomy. ,vol. 100, pp. 409- 433 ,(1957) , 10.1002/AJA.1001000306
G. W. T. H. Fleming, Cerebral Circulation. XII: The Effect on Pial Vessels of Variations in the Oxygen and Carbon Dioxide Content of the Blood. (Arch. of Neur. and Psychiat., June, 1930.) Wolff, H. G., and Lennox, W. G. Journal of Mental Science. ,vol. 76, pp. 817- 818 ,(1930) , 10.1192/BJP.76.315.817-C