Biomimic Oxidation of Glycated Protein and Amadori Product
作者： S. Kawakishi , R.Z. Cheng , S. Sato , K. Uchida
DOI: 10.1533/9781845698393.4.281
关键词: Bovine serum albumin 、 Chemistry 、 Incubation 、 Sugar 、 Chromatography 、 Phosphate buffered saline 、 Glycated protein 、 Oxidative degradation 、 Amadori rearrangement 、 Lysine 、 Biochemistry
摘要: Summary The oxidative degradation of Nα-t-Boc-Ne-fructoselysine (FL) and glycated protein in phosphate buffer solution have been investigated under physiological condition during long time incubation. FL was degraded to mainly lysine, carboxymethyllysine (CML) α-dicarbonyl sugars which contained glucosone, 3-deoxyglucosone (3-DG) 1-deoxy-2, 3-hexodiulose (1-DG). Glucosone a major sugar product corresponded lysine formation, 3-DG 1-DG were minors. Glycated bovine serum albumin (G-BSA) also like FL, glucosone main α-carbonyl compound.
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