PYY[3-36] Administration Decreases the Respiratory Quotient and Reduces Adiposity in Diet-Induced Obese Mice

摘要: In rodents, weight reduction after peptide YY[3-36] (PYY[3-36]) administration may be due largely to decreased food consumption. Effects on other processes affecting energy balance (energy expenditure, fuel partitioning, gut nutrient uptake) remain poorly understood. We examined whether s.c. infusion of 1 mg/(kg x d) PYY[3-36] (for up 7 increased metabolic rate, fat combustion, and/or fecal loss in obese mice fed a high-fat diet. transiently reduced intake (e.g., 25-43% lower at d 2 relative pretreatment baseline) and body 9-10% vs. 3 separate studies. Mass-specific rate kJ/(kg h) PYY[3-36]-treated did not differ from controls. The dark cycle respiratory quotient (RQ) was decreased. On 2, it 0.747 +/- 0.008 compared with 0.786 0.004 for controls (P < 0.001); light RQ throughout the study (0.730 0.006) (0.750 0.009; P 0.001). Epididymal pad approximately 50% than 0.01). Fat lipolysis ex vivo stimulated by PYY[3-36]. basal gallbladder emptying nonobese mice. Fecal negligible ( 2% ingested energy) between Thus, negative diet-induced results maintenance mass-specific expenditure. highlight potential drive mobilization stores help meet requirements this model.