Animal Models of Metabolic Syndrome

摘要: Abstract Metabolic syndrome (MetS) is a clustering of metabolic complications representing premorbid condition that substantial public health burden. Animal models provide an opportunity to examine correlations among different parameters understand why sometimes cluster and do not. This chapter provides overview animal MetS are used etiology pathophysiology, with focus on methods identifying testing candidate genes the aim translating results human studies. Genetic, epigenetic, environmental, gene-by-environmental discussed along important lessons learned. Rodent most frequently used, however, other including dogs, pigs, sheep, nonhuman primates have contributed our understanding each discussed. Additionally, test physiological hypotheses reviewed their potential illuminate DNA sequence—metabolic function relationships inform therapies.