Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality The Framingham Heart Study

摘要: Background— Mitral annular calcification (MAC) has been associated with stroke in longitudinal, community-based cohorts and cardiovascular disease (CVD) outcomes many small retrospective studies. Prospective data are limited on the relation of MAC CVD morbidity mortality. Methods Results— We examined association between assessed by M-mode echocardiography incidence CVD, death, all-cause death over 16 years follow-up Framingham Heart Study subjects who attended a routine examination 1979 1981. Cox proportional hazards models were used to estimate hazard ratios (HRs) presence for each outcome. Of 1197(445 male, 752 female) had adequate echocardiographic assessment, 14% MAC. There 307 incident events 621 deaths. In multivariable adjusted analyses, was an increased risk (HR, 1.5; 95% CI, 1.1, 2.0), 1.6; 2.3), 1.3; 1.04, 1.6). For 1-mm increase MAC, ≈10%. Conclusions— The independent underscores that cardiac is marker risk.