Association between antibodies against calcifying nanoparticles and mitral annular calcification.

摘要: Background and aim of the study: Mechanisms leading to vascular tissue calcification are not yet fully understood. Previously, an association has been demonstrated between a controversial calcifying nanoparticle (CNP; also known as ‘nanobacteria’) kidney stone formation. The study was evaluate possible mitral annular (MAC) CNP infection. Methods: A total 93 patients with MAC, detected using echocardiography, 94 asymptomatic subjects without valvular coronary artery calcification, were enrolled in study. serum levels anti-CNP-antibodies monitored all subjects. Results: Patients MAC generally older had higher prevalence systemic hypertension, diabetes mellitus, dyslipidemia. anti-CNPantibody titers, which significantly associated (p <0.0001), increased age thickness, but decreased line HDL-cholesterol <0.0001). In order provide cut-off point for when detecting receiver operating characteristic curve created. Serum CNP-antibody above 0.19 units/ml showed sensitivity 73%, specificity 72%, positive negative predictive values 72% respectively. Multivariate logistic regression analysis revealed that increasing age, diabetes, high anti-CNP titers risk factors independently annuli. Conclusion: results suggested might play important role pathogenesis MAC.