Corticosteroid treatment of laser retinal damage affects prostaglandin E2 response.

摘要: The current study investigated the effect of steroid treatment eyes subjected to a single retinal argon laser lesion on vitreal accumulation both prostaglandin E2 (PGE2) and protein their relationship with amounts PGE2 released from retina-choroid. Laser exposure resulted in an elevation by retina-choroid laser-treated eyes: there was initial peak day 1, followed higher 7 (13.0 ± 3.9 ng/mg 32.9 4.9 protein, respectively) after which levels progressively declined. Steroid prevented peak, but did not prevent enhanced during second week. Thus, were lower 32% than untreated group (21.0 8.6 vs P = 0.000); 14, however, values treated (32.2 12.4 10.6 4.5 respectively). In steroid-treated eyes, concentration remained unchanged baseline over 2-week follow-up, whereas group, peaked 10.7 3.6 ng/ml, exceeding 5.8 ±1. ng/ml {P 0.0002). also associated biphasic concentrations days 3 14 (0.68 0.16 mg/ml 0.79 0.13 mg/ml, respectively); these significantly value 0.43 0.12 (P 0.03 0.004, concentration, occurring 7, when reached 1.00 0.31 mg/ml. Our demonstrated that laser-induced damage transiently reduced exposed This inhibition occurred phase exposure; at later phase, augmented release resumed. addition, this affected selectively; above completely while lowered only partially. Invest Ophthalmol Vis Sci 31:9-13,1990 Argon lesions have been inflammatory reaction is characterized extensive choroidal polymorphonuclear infiltration 1 ' 2 as well 34 fluorescein leakage 5 6 into vitreous, indicative disruption blood-retinal barrier (BRB). Iris various modalities related elevated aqueous levels, " 9 latter known for its mediatory role reaction, 10 intergrity ocular barriers. changes posterior segment studied.