The regulatory function of sphingosine-1-phosphate signaling axis on regulatory T cells in colorectal cancer
作者： Andrew V. Nguyen , , Yuan-Yuan Wu , Elaine Y. Lin
关键词: Function (biology) 、 Inflammation 、 Sphingosine-1-phosphate 、 Cancer 、 Inflammatory bowel disease 、 Colorectal cancer 、 S1P signaling pathway 、 Immunology 、 Biology
摘要: In tumors associated with inflammation such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), high numbers of regulatory T cells (Tregs) are both favorable poor prognoses. The functions Tregs in CRC remain elusive have yet to be clearly defined. With new evidence supporting many subsets Tregs, the research on development these has begun come fruition. sphingosine 1 phosphate (S1P) pathway was recently reported regulate function cells. This may shine light into pleiotropic nature cancer. this review, we will examine current literature highlight significance S1P signaling Treg development/function implication novel therapeutic strategies treatment patients.
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