Luteinizing hormone-releasing hormone agonist and uterine leiomyoma: a pilot study.
作者： Rodolphe Maheux , Chantal Guilloteau , André Lemay , Adrien Bastide , Atilla T.A. Fazekas
DOI: 10.1016/0002-9378(85)90554-X
关键词: Uterine leiomyoma 、 Hormone 、 Endocrinology 、 Follicle-stimulating hormone 、 Luteinizing hormone 、 Uterine Hemorrhage 、 Internal medicine 、 Medicine 、 Buserelin 、 Agonist 、 Leiomyoma
摘要: Ten women with 12 uterine leiomyomas ranging from 7.5 to 420 cc (mean, 112.6 +/- 39.4) were treated subcutaneous injections of the luteinizing hormone-releasing hormone agonist buserelin, 200 micrograms three times daily for 1 week and then 500 rest 6-month treatment period. Following initial stimulation pituitary ovarian axis was suppressed after 3 weeks mean serum estradiol between 17 36 pg/ml. Seven had a marked regression in size following agonist; two undetectable volume other five diminished by an average 80%. One tumor did not respond treatment, regressed 25%, two, reduction 65% 50%, reenlarged during last 2 months 75% 100% respectively their volume. Luteinizing is first medication demonstrated effective reducing myomas.
sci-hub.se 参考文章(5)
Marco Filicori, Deborah A. Hall, Jacquelyn S. Loughlin, Jean Rivier, Wylie Vale, William F. Crowley, A conservative approach to the management of uterine leiomyoma: Pituitary desensitization by a luteinizing hormone-releasing hormone analogue American Journal of Obstetrics and Gynecology. ,vol. 147, pp. 726- 727 ,(1983) , 10.1016/0002-9378(83)90463-5
K. Pollow, J. Geilfuβ, E. Boquoi, Barbara Pollow, Estrogen and Progesterone Binding Proteins in Normal Human Myometrium and Leiomyoma Tissue Clinical Chemistry and Laboratory Medicine. ,vol. 16, pp. 503- 512 ,(1978) , 10.1515/CCLM.1978.16.9.503
André Lemay, Rodolphe Maheux, Nacia Faure, Clément Jean, Atilla T.A. Fazekas, Reversible hypogonadism induced by a luteinizing hormone-releasing hormone (LH-RH) agonist (Buserelin) as a new therapeutic approach for endometriosis Fertility and Sterility. ,vol. 41, pp. 863- 871 ,(1984) , 10.1016/S0015-0282(16)47899-4
Rodolphe Maheux, Chantale Guilloteau, André Lemay, Adrien Bastide, Atilla T.A. Fazekas, Regression of leiomyomata uteri following hypoestrogenism induced by repetitive luteinizing hormone-releasing hormone agonist treatment: preliminary report Fertility and Sterility. ,vol. 42, pp. 644- 646 ,(1984) , 10.1016/S0015-0282(16)48152-5
André Lemay, Nacia Faure, Fernand Labrie, Sensitivity of pituitary and corpus luteum responses to single intranasal administration of (d-Ser[TBU]6-des-Gly-NH210) luteinizing hormone-releasing hormone ethylamide (Buserelin) in normal women Fertility and Sterility. ,vol. 37, pp. 193- 200 ,(1982) , 10.1016/S0015-0282(16)46038-3