Intermittent LHRH Agonist Sequentially Combined with a Progestogen as Antiovulatory Contraception
作者： A. Lemay , N. Faure
DOI: 10.1007/978-94-009-3229-6_27
关键词: Endometrial biopsy 、 Nasal administration 、 Endocrinology 、 Internal medicine 、 Medroxyprogesterone acetate 、 Progesterone secretion 、 Medicine 、 Ovulation 、 Amenorrhea 、 Follicular phase 、 Progestogen
摘要: Continuous LHRH infusion in normal women leads to pituitary and gonadal desensitization [1]. Once daily intranasal administration of potent agonists consistently blocks ovulation prevents progesterone secretion [2–5]. However under repetitive agonist down-regulation the inhibition follicular activity is variable there a high incidence oligomenorrhea amenorrhea [3–5]. Endometrial biopsies taken after several months treatment indicated inactive endometrium or stages proliferation [6,7]. Potential drawbacks long term could be related persistent state decreased unopposed estrogens.
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