Microrna-formatted multitarget interfering rna vector constructs and methods of using the same

作者: Laura Steel , Catherine J. Pachuk

DOI:

关键词: Molecular biologymicroRNAGeneBiologyComputational biologyRNAVector (molecular biology)RNA silencing

摘要: Vectors expressing multiple microRNA (miRNA)-formatted interfering RNAs from a single transcript are disclosed, and methods of using the same to inhibit expression one or more target genes.

参考文章(5)
Ke Luo, G. Frick, Ling Du, Bidirectional promoters for small RNA expression ,(2004)
David A. Suhy, Jeffery C. Giering, Mark A. Kay, Petrus W. Roelvink, Alexander A. Kolykhalov, RNAi expression constructs with liver-specific enhancer/promoter ,(2006)
Chandrasekhar Satishchandran, Martin D. Sigg, Catherine J. Pachuk, Daniel Edward McCallus, Multiple rna polymerase iii promoter expression constructs ,(2005)
Harvey Lodish, David P. Bartel, Chang-Zheng Chen, Methods and products for expression of micro rnas ,(2004)
Catherine Pachuk, Chandrasekhar Satishchandran, Multiple-compartment eukaryotic expression systems ,(2008)