RNAi expression constructs with liver-specific enhancer/promoter
作者： David A. Suhy , Jeffery C. Giering , Mark A. Kay , Petrus W. Roelvink , Alexander A. Kolykhalov
DOI:
关键词: Enhancer 、 Cell biology 、 Expression (architecture) 、 RNA interference 、 Cancer research 、 Biology
摘要: The present invention provides compositions and methods suitable for RNAi specifically in the liver so as to treat diseases or disorders.
lens.org 参考文章(45)
Michael J Gait, Oligonucleotide synthesis : a practical approach Published in <b>1984</b> in Oxford by IRL press. ,(1984)
Zhi-Ying Chen, Mark A. Kay, Circular nucleic acid vectors, and methods for making and using the same ,(2003)
Peter G. M. Wuts, Theodora W. Greene, Protective groups in organic synthesis ,(1981)
Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel, Abdullah Yalcin, Klaus Weber, Thomas Tuschl, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature. ,vol. 411, pp. 494- 498 ,(2001) , 10.1038/35078107
Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver, Craig C. Mello, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. ,vol. 391, pp. 806- 811 ,(1998) , 10.1038/35888
Michael Wayne Graham, Genetic constructs for delaying or repressing the expression of a target gene ,(1998)
Jianzhu Chen, Herman N Eisen, Qing Ge, Compositions and methods for delivery of short interfering RNA and short hairpin RNA ,(2003)
R. Ashfield, A.J. Patel, S.A. Bossone, H. Brown, R.D. Campbell, K.B. Marcu, N.J. Proudfoot, MAZ-dependent termination between closely spaced human complement genes. The EMBO Journal. ,vol. 13, pp. 5656- 5667 ,(1994) , 10.1002/J.1460-2075.1994.TB06904.X
Tal Kafri, Frederic Bushman, Mark Hansen, Inder M. Verma, Retroviral packaging cell line ,(1999)
S. Karlin, S. F. Altschul, Applications and statistics for multiple high-scoring segments in molecular sequences. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 5873- 5877 ,(1993) , 10.1073/PNAS.90.12.5873