Successful Immunization of Infants With and Without Maternal Antibody by Aerosolized Measles Vaccine

摘要: In 4- and 5-month-old infants in whom the undiluted chick embryo fibroblast (CEF) Schwarz strain measles vaccine had a poor immunogenic effect, there was an increase immunogenicity when high sugar concentration diminished without reference to added albumin. The human diploid cell (HDC) still superior this age group even lower of Ikic, Edmonston-Zagreb virus. More aerosolized, HDC Ikic virus required for seroconversion rates who higher titers prevaccination plaque-neutralizing (PN) antibodies. Some these delayed immune response that absent at six weeks but present three months after vaccination. data provided evidence PN enzyme-linked immunosorbent assay techniques measured different antibodies develop persist ways infants. lyophilized yielded unexpectedly aftersubcutaneousinjection 5,000 plaque-forming units (PFUs) 4-, 5-, 6-month-old infants: 69% 89%, 100%, respectively, 14 weeks. 12- 23-month-old 92% 100% inhalation estimated 175 PFUs CEF 375 vaccine, respectively. Within vaccination, antibody were significantly with (geometric mean titer 2,275) than 343). (JAMA1984;251:2363-2371)