A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium
作者： Stephen Lam , Jean C. leRiche , Annette McWilliams , Calum MacAulay , Yulia Dyachkova
DOI: 10.1158/1078-0432.CCR-04-0686
关键词: Bronchus 、 Dysplasia 、 Lung cancer 、 Internal medicine 、 Budesonide 、 Biopsy 、 Corticosteroid 、 Placebo 、 Gastroenterology 、 Lung 、 Pathology 、 Medicine 、 Cancer research 、 Oncology
摘要: … The primary finding of this study is that in smokers with bronchial dysplasia, inhaled … regression of existing bronchial dysplasia or in prevention of appearance of new dysplastic lesions. …
aacrjournals.org
elsevier.com
highwire.org参考文章(43)
D L Newton, M B Sporn, Chemoprevention of cancer with retinoids. Federation proceedings. ,vol. 38, pp. 2528- 2534 ,(1979)
Ronald A. Lubet, Elizabeth Kastens, Yian Wang, Zhongqiu Zhang, Ming You, Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Research. ,vol. 63, pp. 4389- 4395 ,(2003)
Sara Milchgrub, John D. Minna, John W. Fondon, Adi F. Gazdar, Arvind K. Virmani, Gina Mele, Carmen Behrens, Farida Latif, Michael I. Lerman, Stephen Lam, Harold R. Garner, Bruce McKay, Luc Girard, Ignacio I. Wistuba, High Resolution Chromosome 3p Allelotyping of Human Lung Cancer and Preneoplastic/Preinvasive Bronchial Epithelium Reveals Multiple, Discontinuous Sites of 3p Allele Loss and Three Regions of Frequent Breakpoints Cancer Research. ,vol. 60, pp. 1949- 1960 ,(2000)
Richard D. Estensen, Gary J. Kelloff, Lee W. Wattenberg, Timothy S. Wiedmann, Cheryl L. Zimmerman, Vernon E. Steele, Chemoprevention of Pulmonary Carcinogenesis by Aerosolized Budesonide in Female A/J Mice Cancer Research. ,vol. 57, pp. 5489- 5492 ,(1997)
Annette McWilliams, John Mayo, Sharyn MacDonald, Jean C. leRiche, Branko Palcic, Eva Szabo, Stephen Lam, Lung cancer screening: a different paradigm. American Journal of Respiratory and Critical Care Medicine. ,vol. 168, pp. 1167- 1173 ,(2003) , 10.1164/RCCM.200301-144OC
Sara Milchgrub, John D. Minna, Adi F. Gazdar, Arvind K. Virmani, Carmen Behrens, Stephen Lam, Salahuddin Syed, Bruce Mackay, Ignacio I. Wistuba, Allelic Losses at Chromosome 8p21–23 Are Early and Frequent Events in the Pathogenesis of Lung Cancer Cancer Research. ,vol. 59, pp. 1973- 1979 ,(1999)
Annette McWilliams, Stephen Lam, New approaches to lung cancer prevention Current Oncology Reports. ,vol. 4, pp. 487- 494 ,(2002) , 10.1007/S11912-002-0060-9
Caroline A Heckman, John W Mehew, Linda M Boxer, NF-κB activates Bcl-2 expression in t (14 ; 18) lymphoma cells Oncogene. ,vol. 21, pp. 3898- 3908 ,(2002) , 10.1038/SJ.ONC.1205483
Stephen Lam, Calum MacAulay, Jean C. LeRiche, Adi F. Gazdar, Key issues in lung cancer chemoprevention trials of new agents. Recent results in cancer research. ,vol. 163, pp. 182- 195 ,(2003) , 10.1007/978-3-642-55647-0_17
W. K. Hong, Recent Advances in Chemoprevention of Cancer Science. ,vol. 278, pp. 1073- 1077 ,(1997) , 10.1126/SCIENCE.278.5340.1073