Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment.
作者： Karin Larsson , Per-Johan Jakobsson
DOI: 10.1016/J.PROSTAGLANDINS.2015.06.002
关键词: Prostate cancer 、 Colorectal cancer 、 Breast cancer 、 Prostaglandin E2 、 Prostaglandin E 、 Targeted therapy 、 Carcinogenesis 、 Tumor progression 、 Medicine 、 Pharmacology
摘要: The bioactive lipid prostaglandin E2 (PGE2) is involved in several steps of carcinogenesis some the most common cancers, e.g. colon cancer, lung prostate cancer and breast cancer. Non-steroidal anti-inflammatory drugs (NSAIDs) that target cyclooxygenase (COX) activity, first step PGE2 biosynthesis, has been found to reduce incidence Due severe adverse effects on gastrointestinal tract cardiovascular system, their use as chemopreventing agent hampered. Genetic deletion microsomal E synthase-1 (mPGES-1), enzyme responsible for second resulted reduced tumor progression mouse models Inhibition mPGES-1 would potentially be beneficial a great number patients without side associated with long-term treatment traditional NSAIDs.
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