Design and synthesis of positional isomers of 1-alkyl-2-trifluoromethyl-5 or 6-substituted benzimidazoles and their antimicrobial activity
作者： G Sathaiah , A Ravi Kumar , A Chandra Shekhar , K Raju , P Shanthan Rao
DOI: 10.1007/S00044-012-0131-X
关键词: Candida albicans 、 Rhizopus oryzae 、 Benzimidazole 、 Gram-negative bacteria 、 Gram-positive bacteria 、 Antimicrobial 、 Chemistry 、 Organic chemistry 、 Antibacterial activity 、 Aspergillus niger 、 General Pharmacology, Toxicology and Pharmaceutics
摘要: A series of novel positional isomers 1-alkyl-2-trifluoromethyl benzimidazole derivatives 3a–j and 4a–j have been synthesized screened for antibacterial activity against gram positive bacteria viz, Bacillus subtilis, Staphylococcus aureus negative viz., Escherichia coli, Pseudomonas aeruginosa antifungal Candida albicans, Aspergillus niger, Rhizopus oryzae Saccharomyces cerevisiae. Results indicate that compounds 3b, 4b were having promising activity.
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