Immune Factors in Narcolepsy in the United Kingdom

摘要: In this and the following chapter, we discuss importance of genetic environmental factors in development narcolepsy. Narcolepsy, with a near-100% HLA DR2/DQ relationship (Honda et al. 1984; Langdon Billiard Seignalet 1985), is an ideal neurological disorder which to consider basis disease, despite marked heterogeneity clinical expression. The tight linkage may suggest that are less important than inherited factors, although not necessarily case. contrast narcolepsy, Parkinson’s disease at opposite pole, concordance rates for twin studies lowest any investigated by method (Ward 1984). Unfortunately, insufficient twins narcolepsy have been described as yet help elucidate either or components one intriguing report multiple sclerosis narcolepsy-cataplexy monozygotic pair (Schrader 1980). Other reported Imlah (1961) Mitchell Cummins (1965). For proper assessment it necessary known familial associations presentation, well data laboratory molecular level.