Narcolepsy: a review of evidence for autoimmune diathesis.
作者： John Logan Black
DOI: 10.1080/02646830500381492
关键词: Antibody 、 Disease 、 HLA-DQB1 、 Cerebrospinal fluid 、 Cataplexy 、 Narcolepsy 、 Internal medicine 、 Clinical trial 、 Immunology 、 Autoimmunity 、 Endocrinology 、 Psychology
摘要: Sporadic narcolepsy with cataplexy is a disabling disease that strongly associated the major histocompatibility class II allele HLA DQB1*0602 and characterized by profound reduction in cerebrospinal fluid (CSF) concentration of hypocretin 1 levels. This article provides comprehensive review evidence neurologic autoimmunity pathogenic basis cataplexy. Despite this evidence, specific antibody markers for have been elusive. Clinical trials using intravenous immunoglobulin infusions recent onset led to improvement some patients. Future research must focus on elucidation immune early ameliorative treatments narcolepsy.
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