Mutation Affecting the 12th Amino Acid of the c-Ha-ras Oncogene Product Occurs Infrequently in Human Cancer
作者： A. Feinberg , B Vogelstein , M. Droller , S. Baylin , B. Nelkin
关键词: Oncogene 、 Cancer research 、 Carcinogenesis 、 Amino acid 、 Gene product 、 Mutation (genetic algorithm) 、 Mutagenesis (molecular biology technique) 、 Primary tumor 、 Biology 、 Point mutation
摘要: A point mutation alters the 12th amino acid of c-Ha-ras oncogene product p21 in a human bladder cancer cell line. This is, at present, only known to result transforming gene. may therefore represent possible target for mutagenesis leading carcinogenesis humans. By means restriction enzyme analysis, 29 cancers, including 20 primary tumor tissues, derived from organs commonly exposed environmental carcinogens, were tested presence this mutation. None ten carcinomas exhibited mutation; nor did nine colon or lung. Thus affecting gene product, while valuable model carcinogenesis, does not appear play role development most epithelial cancers bladder, colon,
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