Genetic polymorphism of miR‐146a is associated with gastric cancer risk: a meta‐analysis
作者： Y. Sun , M. Li
DOI: 10.1111/ECC.12355
关键词: Knowledge infrastructure 、 Meta-analysis 、 Cancer risk 、 Oncology 、 Genetic model 、 Internal medicine 、 Medicine 、 Subgroup analysis
摘要: Abstract Several studies have investigated the associations between miR-146a rs2910164 and gastric cancer (GC) risk, but results been inconclusive. To derive a more precise estimation of relationship, meta-analysis was performed. PubMed China National Knowledge Infrastructure searches were carried out for relevant published before July 2014. Meta-analysis performed with stata, version 11.0. A total seven case-control studies, including 3283 cases 4535 controls, selected. significant association found GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC GC+GG, OR = 0.84, CI = 0.71-0.99; CC+GC OR = 0.82, CI = 0.73-0.91) data. In subgroup analysis by ethnicity, statistically in Asian. This suggested that factor developing GC.
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