Photoinduced short-range electron transfer in DNA with fluorescent DNA bases: lessons from ethidium and thiazole orange as charge donors

摘要: Charge transfer processes through the double helix of DNA cover a broad range mechanistic models ranging from superexchange to hopping mechanisms. Over last decade, these were studied by our group in photoinduced fashion since (i) starting time for charge is clearly defined absorption photon and (ii) photoexcitation delivers necessary driving force system. It prerequisite modify oligonucleotides synthetically with suitable organic fluorophores that serve as photoinducable donors. In first part this perspective article we summarize recent advances area DNA-mediated reductive electron over short ranges using synthetic DNA-donor–acceptor systems. The second focuses on ethidium donor. Ethidium-modified can be used compare oxidative hole type controlled choosing right acceptor. Recent results showed an efficient covalently bound strongly influenced mainly dynamics but also several other parameters affect electronic coupling between donor