PEGylation of Phytantriol-Based Lyotropic Liquid Crystalline Particles—The Effect of Lipid Composition, PEG Chain Length, and Temperature on the Internal Nanostructure

摘要: Poly(ethylene glycol)-grafted 1,2-distearoyl-sn-glycero-3-phosphoethanolamines (DSPE-mPEGs) are a family of amphiphilic lipopolymers attractive in formulating injectable long-circulating nanoparticulate drug formulations. In addition to long circulating liposomes, there is an interest developing nanocarriers based on cubosomes and hexosomes by shielding coating the dispersed particles enveloping well-defined internal nonlamellar liquid crystalline nanostructures with hydrophilic PEG segments. The present study attempts shed light possible PEGylation these lipidic using DSPE-mPEGs three different block lengths segment. effects lipid composition, chain length, temperature morphology nanostructure self-assembled aqueous dispersions phytantriol (PHYT) were investigated means synchrotron small-angle X-ray scattering Transmission Electron Cryo-Microscopy. results suggest that used incorporated into water-PHYT interfacial area induce significant effect submicrometer-sized particles. domains functionalized, i.e., nanochannels cubic Pn3m Im3m phases significantly enlarged presence relatively small amounts DSPE-mPEGs. It evident partial replacement PHYT PEGylated lipids could be approach for surface modification cubosomal hexosomal These particularly designing loading drugs and/or imaging probes.