MODULATORY EFFECTS OF 5-HYDROXYTRYPTAMINE ON VOLTAGE-ACTIVATED CURRENTS IN CULTURED ANTENNAL LOBE NEURONES OF THE SPHINX MOTH MANDUCA SEXTA
作者： John G. Hildebrand , Jon H. Hayashi , Alison R. Mercer
关键词: Cell biology 、 Antennal lobe 、 Functional significance 、 Neuroscience 、 Sphinx moth 、 Serotonin 、 Cell culture 、 Biology 、 In vitro 、 Manduca sexta
摘要: The modulatory effects of 5-hydroxytryptamine (5-HT or serotonin) on voltage-gated currents in central olfactory neurones the moth Manduca sexta have been examined vitro using whole-cell patch-clamp recording techniques. Central were dissociated from antennal lobes animals at stage 5 18 stages metamorphic adult development. actions 5-HT voltage-activated ionic a subset morphologically identifiable lobe maintained for 2 weeks primary cell culture. caused reversible reduction both rapidly activating A-type K+ current and relatively slowly resembling delayed rectifier-type conductance. also reduced magnitude Ca2+ influx these cells. functional significance 5-HT-modulation is discussed.
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